The original paper is in English. Non-English content has been machine-translated and may contain typographical errors or mistranslations. ex. Some numerals are expressed as "XNUMX".
Copyrights notice
The original paper is in English. Non-English content has been machine-translated and may contain typographical errors or mistranslations. Copyrights notice
프로그래밍 가능한 미세유체 장치(PMD)를 사용할 때 추가 실험을 위해 칩을 사용하려면 오염된 부분을 씻어야 합니다. 최근에는 Block-Flushing이라는 새로운 세척 기술이 제안되었습니다. Block-Flushing은 버퍼 흐름을 사용하여 PMD의 오염된 영역을 세척합니다. Block-Flushing에서는 잔류 오염물질을 용해시키기 위해 PMD의 입력 포트에서 출력 포트까지 버퍼 흐름을 장기간 유지해야 합니다. 따라서 오염된 면적이 작더라도 많은 완충액과 세척 시간이 필요할 수 있습니다. Block-Flushing에 의한 세척 방식의 또 다른 단점은 버퍼 흐름만으로는 밸브에 잔류하는 오염물질을 완전히 세척할 수 없다는 점입니다. 위에서 언급한 문제를 해결하기 위해 이 논문은 PMD를 세척하는 완전히 새로운 아이디어를 제안합니다. 우리의 방법은 완충류를 사용하지 않고 믹서를 사용하여 오염된 부분을 세척합니다. 믹서를 사용하면 믹서 주변의 밸브에 잔류하는 오염물질을 매우 효율적으로 용해할 수 있습니다. 본 논문에서는 믹서를 이용하여 PMD를 세척하는 두 가지 방법을 제안한다. 첫 번째 방법은 단일 2x2 믹서 시간의 XNUMX배만 사용하여 전체 칩 영역을 세척할 수 있습니다. 또한 밸브를 여러 번 사용하면 마모될 수 있으므로 이동하는 밸브의 수를 줄이기 위한 휴리스틱인 두 번째 방법을 제안합니다. 또한 두 번째 방법이 실제로 사용되는 밸브 수를 줄일 수 있음을 확인하기 위해 몇 가지 실험 결과를 보여줍니다.
Yifang BAO
KuanDeng (Beijing) Science And Technology Ltd.
Shigeru YAMASHITA
Ritsumeikan University
Bing LI
Technical University of Munich
Tsung-Yi HO
the Department of Computer Science of National Tsing Hua University
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부
Yifang BAO, Shigeru YAMASHITA, Bing LI, Tsung-Yi HO, "Mixer-Based Washing Methods for Programmable Microfluidic Devices" in IEICE TRANSACTIONS on Fundamentals,
vol. E105-A, no. 10, pp. 1385-1391, October 2022, doi: 10.1587/transfun.2021EAP1114.
Abstract: When we use a Programmable Microfluidic Device (PMD), we need to wash some contaminated area to use the chip for further experiments. Recently, a novel washing technique called Block-Flushing has been proposed. Block-Flushing washes contaminated area in PMDs by using buffer flows. In Block-Flushing, we need to keep a buffer flow from an input port to an output port of a PMD for a long period to dissolve residual contaminants. Thus, we may need a lot of buffer fluids and washing time even if the contaminated area is small. Another disadvantage of the washing method by Block-Flushing is such that we may not able to clean residual contaminants at valves completely by only buffer flows. To address the above-mentioned issues, this paper proposes a totally new idea to wash PMDs; our method does not use buffer flows, but washes contaminated area by using mixers. By using a mixer, we can dissolve residual contaminants at valves in the area of the mixer very efficiently. In this paper, we propose two methods to wash PMDs by using mixers. The first method can wash the whole chip area by using only four times of a single 2x2-mixer time. We also propose the second method which is a heuristic to reduce the number of moving valves because valves may wear down if they are used many times. We also show some experimental results to confirm that the second method can indeed decrease the number of used valves.
URL: https://global.ieice.org/en_transactions/fundamentals/10.1587/transfun.2021EAP1114/_p
부
@ARTICLE{e105-a_10_1385,
author={Yifang BAO, Shigeru YAMASHITA, Bing LI, Tsung-Yi HO, },
journal={IEICE TRANSACTIONS on Fundamentals},
title={Mixer-Based Washing Methods for Programmable Microfluidic Devices},
year={2022},
volume={E105-A},
number={10},
pages={1385-1391},
abstract={When we use a Programmable Microfluidic Device (PMD), we need to wash some contaminated area to use the chip for further experiments. Recently, a novel washing technique called Block-Flushing has been proposed. Block-Flushing washes contaminated area in PMDs by using buffer flows. In Block-Flushing, we need to keep a buffer flow from an input port to an output port of a PMD for a long period to dissolve residual contaminants. Thus, we may need a lot of buffer fluids and washing time even if the contaminated area is small. Another disadvantage of the washing method by Block-Flushing is such that we may not able to clean residual contaminants at valves completely by only buffer flows. To address the above-mentioned issues, this paper proposes a totally new idea to wash PMDs; our method does not use buffer flows, but washes contaminated area by using mixers. By using a mixer, we can dissolve residual contaminants at valves in the area of the mixer very efficiently. In this paper, we propose two methods to wash PMDs by using mixers. The first method can wash the whole chip area by using only four times of a single 2x2-mixer time. We also propose the second method which is a heuristic to reduce the number of moving valves because valves may wear down if they are used many times. We also show some experimental results to confirm that the second method can indeed decrease the number of used valves.},
keywords={},
doi={10.1587/transfun.2021EAP1114},
ISSN={1745-1337},
month={October},}
부
TY - JOUR
TI - Mixer-Based Washing Methods for Programmable Microfluidic Devices
T2 - IEICE TRANSACTIONS on Fundamentals
SP - 1385
EP - 1391
AU - Yifang BAO
AU - Shigeru YAMASHITA
AU - Bing LI
AU - Tsung-Yi HO
PY - 2022
DO - 10.1587/transfun.2021EAP1114
JO - IEICE TRANSACTIONS on Fundamentals
SN - 1745-1337
VL - E105-A
IS - 10
JA - IEICE TRANSACTIONS on Fundamentals
Y1 - October 2022
AB - When we use a Programmable Microfluidic Device (PMD), we need to wash some contaminated area to use the chip for further experiments. Recently, a novel washing technique called Block-Flushing has been proposed. Block-Flushing washes contaminated area in PMDs by using buffer flows. In Block-Flushing, we need to keep a buffer flow from an input port to an output port of a PMD for a long period to dissolve residual contaminants. Thus, we may need a lot of buffer fluids and washing time even if the contaminated area is small. Another disadvantage of the washing method by Block-Flushing is such that we may not able to clean residual contaminants at valves completely by only buffer flows. To address the above-mentioned issues, this paper proposes a totally new idea to wash PMDs; our method does not use buffer flows, but washes contaminated area by using mixers. By using a mixer, we can dissolve residual contaminants at valves in the area of the mixer very efficiently. In this paper, we propose two methods to wash PMDs by using mixers. The first method can wash the whole chip area by using only four times of a single 2x2-mixer time. We also propose the second method which is a heuristic to reduce the number of moving valves because valves may wear down if they are used many times. We also show some experimental results to confirm that the second method can indeed decrease the number of used valves.
ER -